KEY BENEFITS INCLUDE:
SATORI — The Standard of Performance
Every ingredient in Neurolis is selected for a single reason:
demonstrated, mechanism-backed support for cognitive performance.
Neuroplasticity. Focus. Memory. Neuroprotection.
This document contains the science behind each ingredient,
its mechanism of action, and the research that backs it.
Saffron is derived from the stigmas of Crocus sativus and contains two principal bioactive fractions: crocin (a carotenoid glycoside) and safranal (a volatile aldehyde). Both fractions operate through distinct and complementary neurological mechanisms, together producing a broad-spectrum nootropic and neuroprotective profile. Historically used in Persian and Ayurvedic medicine, saffron has accumulated a substantial body of modern clinical research supporting its role in mood regulation, cognitive enhancement, and long-term brain health.
7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavone that acts as a direct agonist at the TrkB receptor — the primary receptor through which BDNF exerts its neuroplasticity and neuroprotective effects. Unlike most botanical compounds that only modestly modulate BDNF expression, 7,8-DHF directly binds and activates TrkB, triggering downstream signalling cascades that drive synaptic growth, neuronal survival, and cognitive enhancement.
Polygala tenuifolia (Yuan Zhi) is a root herb with a 2,000-year history in Traditional Chinese Medicine, used primarily to sharpen cognition, support memory, and calm the mind. Its principal bioactive constituents — tenuifolin (a triterpenoid saponin) and onjisaponins — have been studied extensively for their acetylcholinesterase-inhibiting and neurotrophin-modulating properties. Polygala operates through mechanisms directly relevant to cholinergic tone, synaptic plasticity, and BDNF expression.
Scutellaria baicalensis (Chinese Skullcap) is a herb whose root contains a rich concentration of flavonoids — primarily baicalein, baicalin, and wogonin. These compounds have been studied for their ability to modulate GABAergic neurotransmission, suppress neuroinflammation, and stabilise dopaminergic signalling. The combined effect is a calming-without-sedating cognitive enhancement profile that reduces cognitive noise from excessive neuronal excitation and inflammatory stress.
Quercetin is one of the most abundant dietary flavonoids and one of the most extensively studied plant-derived anti-inflammatory and antioxidant compounds. In the context of cognitive performance, quercetin's primary relevance lies in its ability to reduce neuroinflammation, neutralise reactive oxygen species in neural tissue, and support mitochondrial energy production in neurons — which are among the most metabolically demanding cells in the body.
Luteolin is a polyphenolic flavone found in a range of medicinal herbs and foods. It has emerged as a compound of significant interest in neuroscience for its exceptional ability to modulate microglial activation — a critical factor in controlling neuroinflammation — as well as its potent antioxidant profile in neural tissue. Luteolin's capacity to cross the blood-brain barrier makes it a uniquely effective neuroinflammation-targeting compound.
Icariin is the principal bioactive flavonoid glycoside of Epimedium (Yin Yang Huo), a herb with centuries of use in Traditional Chinese Medicine for its adaptogenic and cognitive-enhancing properties. In modern neuroscience research, icariin has been investigated for its ability to modulate dopaminergic receptor activity, upregulate BDNF, promote synaptic plasticity, and improve cerebral blood flow — producing a multi-mechanism cognitive enhancement profile.
Bacopa monnieri is one of the most extensively researched nootropic herbs, with a long history of use in Ayurvedic medicine under the name Brahmi. Its principal bioactives — bacosides A and B — operate through multiple complementary mechanisms to enhance synaptic signalling, preserve cholinergic tone, and support the structural remodelling of dendritic networks that underlies memory formation and retention.
Rhodiola rosea is an adaptogenic root native to arctic and mountainous regions of Europe and Asia. Its principal bioactives — salidroside and rosavins — have been studied extensively for their ability to normalise the stress response via the hypothalamic-pituitary-adrenal (HPA) axis, maintain monoamine neurotransmitter balance under psychological and physical stress, and support cognitive performance during periods of high cognitive demand and fatigue.
Neurolis is exactly what I needed for staying focused and locked in while working. Neurolis works fast and kept me locked in, I had ideas, enhanced problem solving abilities, and overall cognitive enhancements. 10/10, will have to keep buying this.
